1p53

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{{STRUCTURE_1p53| PDB=1p53 | SCENE= }}
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'''The Crystal Structure of ICAM-1 D3-D5 fragment'''
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===The Crystal Structure of ICAM-1 D3-D5 fragment===
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==Overview==
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We have determined the 3.0 A crystal structure of the three C-terminal domains 3-5 (D3-D5) of ICAM-1. Combined with the previously known N-terminal two-domain structure (D1D2), a model of an entire ICAM-1 extracellular fragment has been constructed. This model should represent a general architecture of other ICAM family members, particularly ICAM-3 and ICAM-5. The observed intimate dimerization interaction at D4 and a stiff D4-D5 stem-like architecture provide a good structural explanation for the existence of preformed ICAM-1 cis dimers on the cell membrane. Together with another dimerization interface at D1, a band-like one-dimensional linear cluster of ICAM-1 on an antigen-presenting cell (APC) surface can be envisioned, which might explain the formation of an immunological synapse between an activated T cell and APC which is critical for T cell receptor signaling.
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==Disease==
==Disease==
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[[Category: Dimer]]
[[Category: Dimer]]
[[Category: Igsf domain]]
[[Category: Igsf domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:56:31 2008''

Revision as of 19:56, 28 July 2008

Image:1p53.png

Template:STRUCTURE 1p53

Contents

The Crystal Structure of ICAM-1 D3-D5 fragment

Template:ABSTRACT PUBMED 15099525

Disease

Known disease associated with this structure: Malaria, cerebral, susceptibility to OMIM:[147840]

About this Structure

1P53 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for dimerization of ICAM-1 on the cell surface., Yang Y, Jun CD, Liu JH, Zhang R, Joachimiak A, Springer TA, Wang JH, Mol Cell. 2004 Apr 23;14(2):269-76. PMID:15099525

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