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1oxf

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{{STRUCTURE_1oxf| PDB=1oxf | SCENE= }}
{{STRUCTURE_1oxf| PDB=1oxf | SCENE= }}
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'''Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins'''
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===Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins===
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==Overview==
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Much effort has been dedicated to the design of significantly red shifted variants of the green fluorescent protein (GFP) from Aequoria victora (av). These approaches have been based on classical engineering with the 20 canonical amino acids. We report here an expansion of these efforts by incorporation of an amino substituted variant of tryptophan into the "cyan" GFP mutant, which turned it into a "gold" variant. This variant possesses a red shift in emission unprecedented for any avFP, similar to "red" FPs, but with enhanced stability and a very low aggregation tendency. An increasing number of non-natural amino acids are available for chromophore redesign (by engineering of the genetic code) and enable new general strategies to generate novel classes of tailor-made GFP proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 12729742 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12729742}}
==About this Structure==
==About this Structure==
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[[Category: Green fluorescent protein]]
[[Category: Green fluorescent protein]]
[[Category: Tryptophan]]
[[Category: Tryptophan]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:23:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:06:20 2008''

Revision as of 20:06, 28 July 2008

Image:1oxf.png

Template:STRUCTURE 1oxf

Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins

Template:ABSTRACT PUBMED 12729742

About this Structure

1OXF is a Single protein structure of sequence from Cfp marker plasmid pwm1009. Full crystallographic information is available from OCA.

Reference

Expansion of the genetic code enables design of a novel "gold" class of green fluorescent proteins., Bae JH, Rubini M, Jung G, Wiegand G, Seifert MH, Azim MK, Kim JS, Zumbusch A, Holak TA, Moroder L, Huber R, Budisa N, J Mol Biol. 2003 May 16;328(5):1071-81. PMID:12729742

Page seeded by OCA on Mon Jul 28 23:06:20 2008

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