1rhz

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[[Image:1rhz.gif|left|200px]]
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{{Seed}}
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[[Image:1rhz.png|left|200px]]
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{{STRUCTURE_1rhz| PDB=1rhz | SCENE= }}
{{STRUCTURE_1rhz| PDB=1rhz | SCENE= }}
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'''The structure of a protein conducting channel'''
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===The structure of a protein conducting channel===
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==Overview==
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A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms a protein-conducting channel, allowing polypeptides to be transferred across or integrated into membranes. We report the crystal structure of the complex from Methanococcus jannaschii at a resolution of 3.2 A. The structure suggests that one copy of the heterotrimer serves as a functional translocation channel. The alpha-subunit has two linked halves, transmembrane segments 1-5 and 6-10, clamped together by the gamma-subunit. A cytoplasmic funnel leading into the channel is plugged by a short helix. Plug displacement can open the channel into an 'hourglass' with a ring of hydrophobic residues at its constriction. This ring may form a seal around the translocating polypeptide, hindering the permeation of other molecules. The structure also suggests mechanisms for signal-sequence recognition and for the lateral exit of transmembrane segments of nascent membrane proteins into lipid, and indicates binding sites for partners that provide the driving force for translocation.
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The line below this paragraph, {{ABSTRACT_PUBMED_14661030}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14661030 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14661030}}
==About this Structure==
==About this Structure==
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[[Category: Protein translocation]]
[[Category: Protein translocation]]
[[Category: Secy]]
[[Category: Secy]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:31:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:08:35 2008''

Revision as of 20:08, 28 July 2008

Image:1rhz.png

Template:STRUCTURE 1rhz

The structure of a protein conducting channel

Template:ABSTRACT PUBMED 14661030

About this Structure

1RHZ is a Protein complex structure of sequences from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

X-ray structure of a protein-conducting channel., Van den Berg B, Clemons WM Jr, Collinson I, Modis Y, Hartmann E, Harrison SC, Rapoport TA, Nature. 2004 Jan 1;427(6969):36-44. Epub 2003 Dec 3. PMID:14661030

Page seeded by OCA on Mon Jul 28 23:08:35 2008

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