1o9a

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[[Image:1o9a.gif|left|200px]]
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{{Seed}}
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[[Image:1o9a.png|left|200px]]
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{{STRUCTURE_1o9a| PDB=1o9a | SCENE= }}
{{STRUCTURE_1o9a| PDB=1o9a | SCENE= }}
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'''SOLUTION STRUCTURE OF THE COMPLEX OF 1F12F1 FROM FIBRONECTIN WITH B3 FROM FNBB FROM S. DYSGALACTIAE'''
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===SOLUTION STRUCTURE OF THE COMPLEX OF 1F12F1 FROM FIBRONECTIN WITH B3 FROM FNBB FROM S. DYSGALACTIAE===
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==Overview==
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Staphylococcus aureus and Streptococcus pyogenes, two important human pathogens, target host fibronectin (Fn) in their adhesion to and invasion of host cells. Fibronectin-binding proteins (FnBPs), anchored in the bacterial cell wall, have multiple Fn-binding repeats in an unfolded region of the protein. The bacterium-binding site in the amino-terminal domain (1-5F1) of Fn contains five sequential Fn type 1 (F1) modules. Here we show the structure of a streptococcal (S. dysgalactiae) FnBP peptide (B3) in complex with the module pair 1F12F1. This identifies 1F1- and 2F1-binding motifs in B3 that form additional antiparallel beta-strands on sequential F1 modules-the first example of a tandem beta-zipper. Sequence analyses of larger regions of FnBPs from S. pyogenes and S. aureus reveal a repeating pattern of F1-binding motifs that match the pattern of F1 modules in 1-5F1 of Fn. In the process of Fn-mediated invasion of host cells, therefore, the bacterial proteins seem to exploit the modular structure of Fn by forming extended tandem beta-zippers. This work is a vital step forward in explaining the full mechanism of the integrin-dependent FnBP-mediated invasion of host cells.
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The line below this paragraph, {{ABSTRACT_PUBMED_12736686}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12736686 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12736686}}
==About this Structure==
==About this Structure==
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1O9A is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O9A OCA].
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1O9A is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O9A OCA].
==Reference==
==Reference==
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[[Category: Werner, J M.]]
[[Category: Werner, J M.]]
[[Category: Host-pathogen protein complex,cell adhesion,fibronectin]]
[[Category: Host-pathogen protein complex,cell adhesion,fibronectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:32:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:16:31 2008''

Revision as of 20:16, 28 July 2008

Image:1o9a.png

Template:STRUCTURE 1o9a

SOLUTION STRUCTURE OF THE COMPLEX OF 1F12F1 FROM FIBRONECTIN WITH B3 FROM FNBB FROM S. DYSGALACTIAE

Template:ABSTRACT PUBMED 12736686

About this Structure

1O9A is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper., Schwarz-Linek U, Werner JM, Pickford AR, Gurusiddappa S, Kim JH, Pilka ES, Briggs JA, Gough TS, Hook M, Campbell ID, Potts JR, Nature. 2003 May 8;423(6936):177-81. PMID:12736686

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