1xed

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{{STRUCTURE_1xed| PDB=1xed | SCENE= }}
{{STRUCTURE_1xed| PDB=1xed | SCENE= }}
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'''Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR'''
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===Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR===
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==Overview==
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The polymeric immunoglobulin receptor (pIgR) is a type I transmembrane protein that delivers dimeric IgA (dIgA) and pentameric IgM to mucosal secretions. Here, we report the 1.9 A resolution X-ray crystal structure of the N-terminal domain of human pIgR, which binds dIgA in the absence of other pIgR domains with an equilibrium dissociation constant of 300 nM. The structure of pIgR domain 1 reveals a folding topology similar to immunoglobulin variable domains, but with differences in the counterparts of the complementarity determining regions (CDRs), including a helical turn in CDR1 and a CDR3 loop that points away from the other CDRs. The unusual CDR3 loop position prevents dimerization analogous to the pairing of antibody variable heavy and variable light domains. The pIgR domain 1 structure allows interpretation of previous mutagenesis results and structure-based comparisons between pIgR and other IgA receptors.
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(as it appears on PubMed at http://www.pubmed.gov), where 15530357 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15530357}}
==Disease==
==Disease==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:17:02 2008''

Revision as of 20:17, 28 July 2008

Image:1xed.png

Template:STRUCTURE 1xed

Contents

Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR

Template:ABSTRACT PUBMED 15530357

Disease

Known disease associated with this structure: IgA nephropathy, susceptibility to OMIM:[173880]

About this Structure

1XED is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor., Hamburger AE, West AP Jr, Bjorkman PJ, Structure. 2004 Nov;12(11):1925-35. PMID:15530357

Page seeded by OCA on Mon Jul 28 23:17:02 2008

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