1zmf

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{{STRUCTURE_1zmf| PDB=1zmf | SCENE= }}
{{STRUCTURE_1zmf| PDB=1zmf | SCENE= }}
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'''C domain of human cyclophilin-33(hcyp33)'''
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===C domain of human cyclophilin-33(hcyp33)===
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==Overview==
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Cyclophilins (CyPs) are a widespreading protein family in living organisms and possess the activity of peptidyl-prolyl cis-trans isomerase (PPIase), which is inhibited by cyclosporin A (CsA). The human nuclear cyclophilin (hCyP33) is the first protein which was found to contain two RNA binding domains at the amino-terminus and a PPIase domain at the carboxyl-terminus. We isolated the hCyP33 gene from the human hematopoietic stem/progenitor cells and expressed it in Escherichia coli, and determined the crystal structure of the C domain of hCyP33 at 1.88 A resolution. The core structure is a beta-barrel covered by two alpha-helices. Superposition of the structure of the C domain of hCyP33 with the structure of CypA suggests that the C domain contains PPIase active site which binds to CsA. Furthermore, C domain seems to be able to bind with the Gag-encoded capsid (CA) of HIV-1 and may affect the viral replication of HIV-1. A key residue of the active site is changed from Ala-103-CypA to Ser-239-hCyP33, which may affect the PPIase domain/substrates interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 15963461 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15963461}}
==About this Structure==
==About this Structure==
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[[Category: Human cyclophilin-33]]
[[Category: Human cyclophilin-33]]
[[Category: Ppiase]]
[[Category: Ppiase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:48:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:19:18 2008''

Revision as of 20:19, 28 July 2008

Image:1zmf.png

Template:STRUCTURE 1zmf

C domain of human cyclophilin-33(hcyp33)

Template:ABSTRACT PUBMED 15963461

About this Structure

1ZMF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1.88 A crystal structure of the C domain of hCyP33: a novel domain of peptidyl-prolyl cis-trans isomerase., Wang T, Yun CH, Gu SY, Chang WR, Liang DC, Biochem Biophys Res Commun. 2005 Aug 5;333(3):845-9. PMID:15963461

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