2vep

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[[Image:2vep.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2vep| PDB=2vep | SCENE= }}
{{STRUCTURE_2vep| PDB=2vep | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE FULL LENGTH BIFUNCTIONAL ENZYME PRIA'''
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===CRYSTAL STRUCTURE OF THE FULL LENGTH BIFUNCTIONAL ENZYME PRIA===
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==Overview==
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Two structures of phosphoribosyl isomerase A (PriA) from Streptomyces coelicolor, involved in both histidine and tryptophan biosynthesis, were solved at 1.8A resolution. A closed conformer was obtained, which represents the first complete structure of PriA, revealing hitherto unnoticed molecular interactions and the occurrence of conformational changes. Inspection of these conformers, including ligand-docking simulations, allowed identification of residues involved in substrate recognition, chemical catalysis and conformational changes. These predictions were validated by mutagenesis and functional analysis. Arg19 and Ser81 were shown to play critical roles within the carboxyl and amino phosphate-binding sites, respectively; the catalytic residues Asp11 and Asp130 are responsible for both activities; and Thr166 and Asp171, which make an unusual contact, are likely to elicit the conformational changes needed for adopting the active site architectures. This represents the first report of the structure/function relationship of this (betaalpha)8-isomerase.
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The line below this paragraph, {{ABSTRACT_PUBMED_17967415}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17967415 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17967415}}
==About this Structure==
==About this Structure==
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[[Category: Pria]]
[[Category: Pria]]
[[Category: Tryptophan biosynthesis]]
[[Category: Tryptophan biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:40:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:20:55 2008''

Revision as of 20:21, 28 July 2008

Image:2vep.png

Template:STRUCTURE 2vep

CRYSTAL STRUCTURE OF THE FULL LENGTH BIFUNCTIONAL ENZYME PRIA

Template:ABSTRACT PUBMED 17967415

About this Structure

2VEP is a Single protein structure of sequence from Streptomyces coelicolor. Full crystallographic information is available from OCA.

Reference

The structure/function relationship of a dual-substrate (betaalpha)8-isomerase., Wright H, Noda-Garcia L, Ochoa-Leyva A, Hodgson DA, Fulop V, Barona-Gomez F, Biochem Biophys Res Commun. 2008 Jan 4;365(1):16-21. Epub 2007 Oct 29. PMID:17967415

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