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1v4s

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{{STRUCTURE_1v4s| PDB=1v4s | SCENE= }}
{{STRUCTURE_1v4s| PDB=1v4s | SCENE= }}
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'''Crystal structure of human glucokinase'''
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===Crystal structure of human glucokinase===
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==Overview==
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Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal saturation curve for its substrate, two properties that are important for its playing the role of a glucose sensor in pancreas and liver. The molecular basis for these two properties is not well understood. Herein we report the crystal structures of glucokinase in its active and inactive forms, which demonstrate that global conformational change, including domain reorganization, is induced by glucose binding. This suggests that the positive cooperativity of monomeric glucokinase obeys the "mnemonical mechanism" rather than the well-known concerted model. These structures also revealed an allosteric site through which small molecules may modulate the kinetic properties of the enzyme. This finding provided the mechanistic basis for activation of glucokinase as a potential therapeutic approach for treating type 2 diabetes mellitus.
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{{ABSTRACT_PUBMED_15016359}}
==About this Structure==
==About this Structure==
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[[Category: Diabetes]]
[[Category: Diabetes]]
[[Category: Hexokinase iv]]
[[Category: Hexokinase iv]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:25:39 2008''

Revision as of 20:25, 28 July 2008

Image:1v4s.png


PDB ID 1v4s

Drag the structure with the mouse to rotate
1v4s, resolution 2.30Å ()
Ligands: , ,
Activity: Hexokinase, with EC number 2.7.1.1
Related: 1v4t
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Crystal structure of human glucokinase

Template:ABSTRACT PUBMED 15016359

About this Structure

1V4S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase., Kamata K, Mitsuya M, Nishimura T, Eiki J, Nagata Y, Structure. 2004 Mar;12(3):429-38. PMID:15016359

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