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1sdd

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{{STRUCTURE_1sdd| PDB=1sdd | SCENE= }}
{{STRUCTURE_1sdd| PDB=1sdd | SCENE= }}
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'''Crystal Structure of Bovine Factor Vai'''
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===Crystal Structure of Bovine Factor Vai===
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==Overview==
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In vertebrate hemostasis, factor Va serves as the cofactor in the prothrombinase complex that results in a 300,000-fold increase in the rate of thrombin generation compared with factor Xa alone. Structurally, little is known about the mechanism by which factor Va alters catalysis within this complex. Here, we report a crystal structure of protein C inactivated factor Va (A1.A3-C1-C2) that depicts a previously uncharacterized domain arrangement. This orientation has implications for binding to membranes essential for function. A high-affinity calcium-binding site and a copper-binding site have both been identified. Surprisingly, neither shows a direct involvement in chain association. This structure represents the largest physiologically relevant fragment of factor Va solved to date and provides a new scaffold for the future generation of models of coagulation cofactors.
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(as it appears on PubMed at http://www.pubmed.gov), where 15184653 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15184653}}
==About this Structure==
==About this Structure==
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[[Category: Cofactor]]
[[Category: Cofactor]]
[[Category: Copper-binding protein]]
[[Category: Copper-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:34:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:25:44 2008''

Revision as of 20:25, 28 July 2008

Image:1sdd.png

Template:STRUCTURE 1sdd

Crystal Structure of Bovine Factor Vai

Template:ABSTRACT PUBMED 15184653

About this Structure

1SDD is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

The crystal structure of activated protein C-inactivated bovine factor Va: Implications for cofactor function., Adams TE, Hockin MF, Mann KG, Everse SJ, Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8918-23. Epub 2004 Jun 7. PMID:15184653

Page seeded by OCA on Mon Jul 28 23:25:44 2008

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