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2opz

From Proteopedia

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[[Image:2opz.gif|left|200px]]
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{{STRUCTURE_2opz| PDB=2opz | SCENE= }}
{{STRUCTURE_2opz| PDB=2opz | SCENE= }}
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'''AVPF bound to BIR3-XIAP'''
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===AVPF bound to BIR3-XIAP===
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==Overview==
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A small series of peptide mimics was designed and synthesized to contain a heterocyclic ring in place of the potentially labile N-terminal peptide bond of the tetrapeptide containing the Smac-XIAP-binding motif. Two Smac mimics were shown to bind to the BIR3 domain of XIAP with moderate affinity and one displayed increased activity in cells relative to the Smac peptides. The structures of BIR3-XIAP in complex with a Smac peptide and a peptide mimic were solved and analyzed to elucidate the structure-activity relationship surrounding the Smac-binding domain within BIR3-XIAP.
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(as it appears on PubMed at http://www.pubmed.gov), where 17336535 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17336535}}
==About this Structure==
==About this Structure==
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[[Category: Bir3 domain of xiap]]
[[Category: Bir3 domain of xiap]]
[[Category: Tetrapeptide]]
[[Category: Tetrapeptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:25:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:25:51 2008''

Revision as of 20:25, 28 July 2008

Image:2opz.png

Template:STRUCTURE 2opz

AVPF bound to BIR3-XIAP

Template:ABSTRACT PUBMED 17336535

About this Structure

2OPZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP., Wist AD, Gu L, Riedl SJ, Shi Y, McLendon GL, Bioorg Med Chem. 2007 Apr 15;15(8):2935-43. Epub 2007 Feb 11. PMID:17336535

Page seeded by OCA on Mon Jul 28 23:25:51 2008

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