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1spd

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[[Image:1spd.gif|left|200px]]
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{{Seed}}
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[[Image:1spd.png|left|200px]]
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{{STRUCTURE_1spd| PDB=1spd | SCENE= }}
{{STRUCTURE_1spd| PDB=1spd | SCENE= }}
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'''AMYOTROPHIC LATERAL SCLEROSIS AND STRUCTURAL DEFECTS IN CU,ZN SUPEROXIDE DISMUTASE'''
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===AMYOTROPHIC LATERAL SCLEROSIS AND STRUCTURAL DEFECTS IN CU,ZN SUPEROXIDE DISMUTASE===
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==Overview==
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Single-site mutants in the Cu,Zn superoxide dismutase (SOD) gene (SOD1) occur in patients with the fatal neurodegenerative disorder familial amyotrophic lateral sclerosis (FALS). Complete screening of the SOD1 coding region revealed that the mutation Ala4 to Val in exon 1 was the most frequent one; mutations were identified in exons 2, 4, and 5 but not in the active site region formed by exon 3. The 2.4 A crystal structure of human SOD, along with two other SOD structures, established that all 12 observed FALS mutant sites alter conserved interactions critical to the beta-barrel fold and dimer contact, rather than catalysis. Red cells from heterozygotes had less than 50 percent normal SOD activity, consistent with a structurally defective SOD dimer. Thus, defective SOD is linked to motor neuron death and carries implications for understanding and possible treatment of FALS.
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(as it appears on PubMed at http://www.pubmed.gov), where 8351519 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8351519}}
==About this Structure==
==About this Structure==
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[[Category: Parge, H E.]]
[[Category: Parge, H E.]]
[[Category: Tainer, J A.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:58:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:36:42 2008''

Revision as of 20:36, 28 July 2008

Image:1spd.png

Template:STRUCTURE 1spd

AMYOTROPHIC LATERAL SCLEROSIS AND STRUCTURAL DEFECTS IN CU,ZN SUPEROXIDE DISMUTASE

Template:ABSTRACT PUBMED 8351519

About this Structure

1SPD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase., Deng HX, Hentati A, Tainer JA, Iqbal Z, Cayabyab A, Hung WY, Getzoff ED, Hu P, Herzfeldt B, Roos RP, et al., Science. 1993 Aug 20;261(5124):1047-51. PMID:8351519

Page seeded by OCA on Mon Jul 28 23:36:42 2008

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