1u5s

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1u5s.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1u5s.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1u5s| PDB=1u5s | SCENE= }}
{{STRUCTURE_1u5s| PDB=1u5s | SCENE= }}
-
'''NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain'''
+
===NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain===
-
==Overview==
+
<!--
-
Weak protein-protein interactions (PPIs) (K(D) &gt; 10(-6) M) are critical determinants of many biological processes. However, in contrast to a large growing number of well-characterized, strong PPIs, the weak PPIs, especially those with K(D) &gt; 10(-4) M, are poorly explored. Genome wide, there exist few 3D structures of weak PPIs with K(D) &gt; 10(-4) M, and none with K(D) &gt; 10(-3) M. Here, we report the NMR structure of an extremely weak focal adhesion complex (K(D) approximately 3 x 10(-3) M) between Nck-2 SH3 domain and PINCH-1 LIM4 domain. The structure exhibits a remarkably small and polar interface with distinct binding modes for both SH3 and LIM domains. Such an interface suggests a transient Nck-2/PINCH-1 association process that may trigger rapid focal adhesion turnover during integrin signaling. Genetic rescue experiments demonstrate that this interface is indeed involved in mediating cell shape change and migration. Together, the data provide a molecular basis for an ultraweak PPI in regulating focal adhesion dynamics during integrin signaling.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15721255}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15721255 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15721255}}
==About this Structure==
==About this Structure==
-
1U5S is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5S OCA].
+
1U5S is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5S OCA].
==Reference==
==Reference==
Line 33: Line 37:
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:47:29 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:38:38 2008''

Revision as of 20:38, 28 July 2008

Image:1u5s.png

Template:STRUCTURE 1u5s

NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain

Template:ABSTRACT PUBMED 15721255

About this Structure

1U5S is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility., Vaynberg J, Fukuda T, Chen K, Vinogradova O, Velyvis A, Tu Y, Ng L, Wu C, Qin J, Mol Cell. 2005 Feb 18;17(4):513-23. PMID:15721255

Page seeded by OCA on Mon Jul 28 23:38:38 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1u5s"
Personal tools