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1nl4

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[[Image:1nl4.jpg|left|200px]]
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{{STRUCTURE_1nl4| PDB=1nl4 | SCENE= }}
{{STRUCTURE_1nl4| PDB=1nl4 | SCENE= }}
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'''Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor'''
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===Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor===
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==Overview==
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A series of imidazole-containing biphenyls was prepared and evaluated in vitro for inhibition of FTase and cellular Ras processing. Several of these analogues, such as 21, are potent inhibitors of FTase (&lt;1nM), FTase/GGTase selective (&gt;300-fold) and cellularly active (&lt;or=80nM). An X-ray crystal structure of inhibitor 21 bound to rat farnesyltransferase is also presented.
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(as it appears on PubMed at http://www.pubmed.gov), where 12657284 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12657284}}
==About this Structure==
==About this Structure==
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[[Category: Prenyltransferase]]
[[Category: Prenyltransferase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:39:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:47:23 2008''

Revision as of 20:47, 28 July 2008

Image:1nl4.png

Template:STRUCTURE 1nl4

Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor

Template:ABSTRACT PUBMED 12657284

About this Structure

1NL4 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase., Curtin ML, Florjancic AS, Cohen J, Gu WZ, Frost DJ, Muchmore SW, Sham HL, Bioorg Med Chem Lett. 2003 Apr 7;13(7):1367-71. PMID:12657284

Page seeded by OCA on Mon Jul 28 23:47:23 2008

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