1n33

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{{STRUCTURE_1n33| PDB=1n33 | SCENE= }}
{{STRUCTURE_1n33| PDB=1n33 | SCENE= }}
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'''Structure of the Thermus thermophilus 30S ribosomal subunit bound to codon and near-cognate transfer rna anticodon stem-loop mismatched at the second codon position at the a site with paromomycin'''
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===Structure of the Thermus thermophilus 30S ribosomal subunit bound to codon and near-cognate transfer rna anticodon stem-loop mismatched at the second codon position at the a site with paromomycin===
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==Overview==
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A structural and mechanistic explanation for the selection of tRNAs by the ribosome has been elusive. Here, we report crystal structures of the 30S ribosomal subunit with codon and near-cognate tRNA anticodon stem loops bound at the decoding center and compare affinities of equivalent complexes in solution. In ribosomal interactions with near-cognate tRNA, deviation from Watson-Crick geometry results in uncompensated desolvation of hydrogen-bonding partners at the codon-anticodon minor groove. As a result, the transition to a closed form of the 30S induced by cognate tRNA is unfavorable for near-cognate tRNA unless paromomycin induces part of the rearrangement. We conclude that stabilization of a closed 30S conformation is required for tRNA selection, and thereby structurally rationalize much previous data on translational fidelity.
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The line below this paragraph, {{ABSTRACT_PUBMED_12464183}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12464183 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12464183}}
==About this Structure==
==About this Structure==
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[[Category: Trna]]
[[Category: Trna]]
[[Category: Wobble]]
[[Category: Wobble]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:01:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:48:08 2008''

Revision as of 20:48, 28 July 2008

Image:1n33.png

Template:STRUCTURE 1n33

Structure of the Thermus thermophilus 30S ribosomal subunit bound to codon and near-cognate transfer rna anticodon stem-loop mismatched at the second codon position at the a site with paromomycin

Template:ABSTRACT PUBMED 12464183

About this Structure

1N33 is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Selection of tRNA by the ribosome requires a transition from an open to a closed form., Ogle JM, Murphy FV, Tarry MJ, Ramakrishnan V, Cell. 2002 Nov 27;111(5):721-32. PMID:12464183

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