2hkk

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{{STRUCTURE_2hkk| PDB=2hkk | SCENE= }}
{{STRUCTURE_2hkk| PDB=2hkk | SCENE= }}
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'''Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms'''
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===Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms===
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==Overview==
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The activation of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) with L-adrenaline and histamine has been investigated by kinetic and X-ray crystallographic studies. L-Adrenaline behaves as a potent activator of isozyme CA I (activation constant of 90 nM), being a much weaker activator of isozyme CA II (activation constant of 96 microM). Isoforms CA IV, VA, VII, and XIV were activated by L-adrenaline with K(A)s in the range of 36-63 microM. The X-ray crystal structure of the CA II-L-adrenaline adduct revealed that the activator plugs the entrance of the active site cavity, obstructing it almost completely.
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(as it appears on PubMed at http://www.pubmed.gov), where 17127057 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17127057}}
==About this Structure==
==About this Structure==
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[[Category: Carbonic anhydrase]]
[[Category: Carbonic anhydrase]]
[[Category: Crystal structure]]
[[Category: Crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:24:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:48:43 2008''

Revision as of 20:48, 28 July 2008

Image:2hkk.png

Template:STRUCTURE 2hkk

Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms

Template:ABSTRACT PUBMED 17127057

About this Structure

2HKK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV., Temperini C, Innocenti A, Scozzafava A, Mastrolorenzo A, Supuran CT, Bioorg Med Chem Lett. 2007 Feb 1;17(3):628-35. Epub 2006 Nov 15. PMID:17127057

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