1s1s

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[[Image:1s1s.gif|left|200px]]
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{{STRUCTURE_1s1s| PDB=1s1s | SCENE= }}
{{STRUCTURE_1s1s| PDB=1s1s | SCENE= }}
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'''Crystal Structure of ZipA in complex with indoloquinolizin 10b'''
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===Crystal Structure of ZipA in complex with indoloquinolizin 10b===
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==Overview==
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The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water.
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(as it appears on PubMed at http://www.pubmed.gov), where 15006376 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15006376}}
==About this Structure==
==About this Structure==
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[[Category: Tuckman, M.]]
[[Category: Tuckman, M.]]
[[Category: Cell cycle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:11:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:51:39 2008''

Revision as of 20:51, 28 July 2008

Image:1s1s.png

Template:STRUCTURE 1s1s

Crystal Structure of ZipA in complex with indoloquinolizin 10b

Template:ABSTRACT PUBMED 15006376

About this Structure

1S1S is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction., Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Li Y, Sukhdeo MN, Ding W, Dushin EG, Kenny CH, Moghazeh SL, Petersen PJ, Ruzin AV, Tuckman M, Sutherland AG, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1427-31. PMID:15006376

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