1s9l

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{{STRUCTURE_1s9l| PDB=1s9l | SCENE= }}
{{STRUCTURE_1s9l| PDB=1s9l | SCENE= }}
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'''NMR Solution Structure of a Parallel LNA Quadruplex'''
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===NMR Solution Structure of a Parallel LNA Quadruplex===
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==Overview==
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The solution structure of a locked nucleic acid (LNA) quadruplex, formed by the oligomer d(TGGGT), containing only conformationally restricted LNA residues is reported. NMR and CD spectroscopy, as well as molecular dynamics and mechanic calculations, has been used to characterize the complex. The molecule adopts a parallel stranded conformation with a 4-fold rotational symmetry, showing a right-handed helicity and the guanine residues in an almost planar conformation with three well-defined G-tetrads. The thermal stability of Q-LNA has been found to be comparable with that of [r(UGGGU)]4, while a T(m) increment of 20 degrees C with respect to the corresponding DNA quadruplex structure [d(TGGGT)]4 has been observed. The structural features of the LNA quadruplex reported here may open new perspectives for the biological application of LNAs as novel versatile tools to design aptamer or catalyst oligonucleotides.
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(as it appears on PubMed at http://www.pubmed.gov), where 15181173 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15181173}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9L OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9L OCA].
==Reference==
==Reference==
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[[Category: Lna]]
[[Category: Lna]]
[[Category: Quadruplex]]
[[Category: Quadruplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:27:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:52:47 2008''

Revision as of 20:52, 28 July 2008

Image:1s9l.png

Template:STRUCTURE 1s9l

NMR Solution Structure of a Parallel LNA Quadruplex

Template:ABSTRACT PUBMED 15181173

About this Structure

Full experimental information is available from OCA.

Reference

NMR solution structure of a parallel LNA quadruplex., Randazzo A, Esposito V, Ohlenschlager O, Ramachandran R, Mayola L, Nucleic Acids Res. 2004 Jun 4;32(10):3083-92. Print 2004. PMID:15181173

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