2on9

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{{STRUCTURE_2on9| PDB=2on9 | SCENE= }}
{{STRUCTURE_2on9| PDB=2on9 | SCENE= }}
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'''Structure of an amyloid forming peptide VQIVYK from the repeat region of Tau'''
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===Structure of an amyloid forming peptide VQIVYK from the repeat region of Tau===
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==Overview==
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Amyloid fibrils formed from different proteins, each associated with a particular disease, contain a common cross-beta spine. The atomic architecture of a spine, from the fibril-forming segment GNNQQNY of the yeast prion protein Sup35, was recently revealed by X-ray microcrystallography. It is a pair of beta-sheets, with the facing side chains of the two sheets interdigitated in a dry 'steric zipper'. Here we report some 30 other segments from fibril-forming proteins that form amyloid-like fibrils, microcrystals, or usually both. These include segments from the Alzheimer's amyloid-beta and tau proteins, the PrP prion protein, insulin, islet amyloid polypeptide (IAPP), lysozyme, myoglobin, alpha-synuclein and beta(2)-microglobulin, suggesting that common structural features are shared by amyloid diseases at the molecular level. Structures of 13 of these microcrystals all reveal steric zippers, but with variations that expand the range of atomic architectures for amyloid-like fibrils and offer an atomic-level hypothesis for the basis of prion strains.
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The line below this paragraph, {{ABSTRACT_PUBMED_17468747}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17468747 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17468747}}
==About this Structure==
==About this Structure==
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[[Category: Parallel face-to-face-up/up beta sheet]]
[[Category: Parallel face-to-face-up/up beta sheet]]
[[Category: Steric zipper]]
[[Category: Steric zipper]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:15:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:55:56 2008''

Revision as of 20:56, 28 July 2008

Image:2on9.png

Template:STRUCTURE 2on9

Structure of an amyloid forming peptide VQIVYK from the repeat region of Tau

Template:ABSTRACT PUBMED 17468747

About this Structure

Full crystallographic information is available from OCA.

Reference

Atomic structures of amyloid cross-beta spines reveal varied steric zippers., Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AO, Riekel C, Eisenberg D, Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29. PMID:17468747

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