2b5n

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{{STRUCTURE_2b5n| PDB=2b5n | SCENE= }}
{{STRUCTURE_2b5n| PDB=2b5n | SCENE= }}
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'''Crystal Structure of the DDB1 BPB Domain'''
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===Crystal Structure of the DDB1 BPB Domain===
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==Overview==
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The DDB1-Cul4A ubiquitin ligase complex promotes protein ubiquitination in diverse cellular functions and is reprogrammed by the V proteins of paramyxoviruses to degrade STATs and block interferon signaling. Here we report the crystal structures of DDB1 alone and in complex with the simian virus 5 V protein. The DDB1 structure reveals an intertwined three-propeller cluster, which contains two tightly coupled beta propellers with a large pocket in between and a third beta propeller flexibly attached on the side. The rigid double-propeller fold of DDB1 is targeted by the viral V protein, which inserts an entire helix into the double-propeller pocket, whereas the third propeller domain docks DDB1 to the N terminus of the Cul4A scaffold. Together, these results not only provide structural insights into how the virus hijacks the DDB1-Cul4A ubiquitin ligase but also establish a structural framework for understanding the multiple functions of DDB1 in the uniquely assembled cullin-RING E3 machinery.
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{{ABSTRACT_PUBMED_16413485}}
==About this Structure==
==About this Structure==
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[[Category: Ddb1]]
[[Category: Ddb1]]
[[Category: Propeller cluster]]
[[Category: Propeller cluster]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:53:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:56:47 2008''

Revision as of 20:56, 28 July 2008

Image:2b5n.png

Template:STRUCTURE 2b5n

Crystal Structure of the DDB1 BPB Domain

Template:ABSTRACT PUBMED 16413485

About this Structure

2B5N is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase., Li T, Chen X, Garbutt KC, Zhou P, Zheng N, Cell. 2006 Jan 13;124(1):105-17. PMID:16413485

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