1te0

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{{STRUCTURE_1te0| PDB=1te0 | SCENE= }}
{{STRUCTURE_1te0| PDB=1te0 | SCENE= }}
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'''Structural analysis of DegS, a stress sensor of the bacterial periplasm'''
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===Structural analysis of DegS, a stress sensor of the bacterial periplasm===
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==Overview==
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Regulated proteolysis is a key event in transmembrane signalling between intracellular compartments. In Escherichia coli the membrane-bound protease DegS has been identified as the periplasmic stress sensor for unfolded outer membrane proteins (OMPs). DegS inititates a proteolytic cascade resulting in the release of sigmaE the transcription factor of periplasmic genes. The crystal structure of DegS protease reported at 2.2 A resolution reveals a trimeric complex with the monomeric protease domain in an inhibited state followed by the inhibitory PDZ domain. Noteably, domain architecture and communication of DegS are remarkably to homologous proteins known to date. Here the domain interface is mechanically locked by three intradomain salt bridges. Co-crystallisation trials in the presence of a 10-residue activating peptide did not result in significant structural intradomain shifts nor distortions in the crystal packing. These observations imply a mode of activation indicative of peptide-induced structural shifts imposed to the protease domain rather than disturbing the PDZ-protease interface.
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The line below this paragraph, {{ABSTRACT_PUBMED_15225661}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15225661 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15225661}}
==About this Structure==
==About this Structure==
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[[Category: Two domain]]
[[Category: Two domain]]
[[Category: X-ray structure]]
[[Category: X-ray structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:50:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:58:02 2008''

Revision as of 20:58, 28 July 2008

Image:1te0.png

Template:STRUCTURE 1te0

Structural analysis of DegS, a stress sensor of the bacterial periplasm

Template:ABSTRACT PUBMED 15225661

About this Structure

1TE0 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural analysis of DegS, a stress sensor of the bacterial periplasm., Zeth K, FEBS Lett. 2004 Jul 2;569(1-3):351-8. PMID:15225661

Page seeded by OCA on Mon Jul 28 23:58:02 2008

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