1t3j

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{{STRUCTURE_1t3j| PDB=1t3j | SCENE= }}
{{STRUCTURE_1t3j| PDB=1t3j | SCENE= }}
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'''Mitofusin domain HR2 V686M/I708M mutant'''
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===Mitofusin domain HR2 V686M/I708M mutant===
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==Overview==
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Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that mitofusin, an integral mitochondrial membrane protein, is required on adjacent mitochondria to mediate fusion, which indicates that mitofusin complexes act in trans (that is, between adjacent mitochondria). A heptad repeat region (HR2) mediates mitofusin oligomerization by assembling a dimeric, antiparallel coiled coil. The transmembrane segments are located at opposite ends of the 95 angstrom coiled coil and provide a mechanism for organelle tethering. Consistent with this proposal, truncated mitofusin, in an HR2-dependent manner, causes mitochondria to become apposed with a uniform gap. Our results suggest that HR2 functions as a mitochondrial tether before fusion.
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{{ABSTRACT_PUBMED_15297672}}
==About this Structure==
==About this Structure==
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[[Category: Coiled coil antiparallel]]
[[Category: Coiled coil antiparallel]]
[[Category: Dimer]]
[[Category: Dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:28:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:58:12 2008''

Revision as of 20:58, 28 July 2008

Template:STRUCTURE 1t3j

Mitofusin domain HR2 V686M/I708M mutant

Template:ABSTRACT PUBMED 15297672

About this Structure

1T3J is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of mitochondrial tethering by mitofusin complexes., Koshiba T, Detmer SA, Kaiser JT, Chen H, McCaffery JM, Chan DC, Science. 2004 Aug 6;305(5685):858-62. PMID:15297672

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