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1uek

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{{STRUCTURE_1uek| PDB=1uek | SCENE= }}
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'''Crystal structure of 4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase'''
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===Crystal structure of 4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase===
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==Overview==
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The crystal structure of the enzyme 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol (CDP-ME) kinase from the thermophilic bacterium Thermus thermophilus HB8 has been determined at 1.7-A resolution. This enzyme catalyzes phosphorylation of the 2-hydroxyl group of CDP-ME, the fourth step of the non-mevalonate pathway, which is essential for isoprenoid biosynthesis in several pathogenic microorganisms. Since this pathway is absent in humans, it is an important target for the development of novel antimicrobial compounds. The structure of the enzyme is similar to the structures of mevalonate kinase and homoserine kinase, members of the GHMP superfamily. Lys8 and Asp125 are active site residues in mevalonate kinase that also appear to play a catalytic role in CDP-ME kinase. Both the mevalonate and the non-mevalonate pathways therefore involve closely related kinases with similar mechanisms. Assaying the enzyme showed that CDP-ME kinase will phosphorylate CDP-ME but not 4-(uridine 5'-diphospho)-2-C-methyl-D-erythritol, indicating the substrate pyrimidine moiety is involved in important interactions with the enzyme.
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(as it appears on PubMed at http://www.pubmed.gov), where 12771135 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12771135}}
==About this Structure==
==About this Structure==
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[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:06:45 2008''
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Revision as of 20:59, 28 July 2008

Image:1uek.png

Template:STRUCTURE 1uek

Crystal structure of 4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase

Template:ABSTRACT PUBMED 12771135

About this Structure

1UEK is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis., Wada T, Kuzuyama T, Satoh S, Kuramitsu S, Yokoyama S, Unzai S, Tame JR, Park SY, J Biol Chem. 2003 Aug 8;278(32):30022-7. Epub 2003 May 27. PMID:12771135

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