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1qix

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[[Image:1qix.jpg|left|200px]]
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{{Seed}}
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[[Image:1qix.png|left|200px]]
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{{STRUCTURE_1qix| PDB=1qix | SCENE= }}
{{STRUCTURE_1qix| PDB=1qix | SCENE= }}
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'''PORCINE PANCREATIC ELASTASE COMPLEXED WITH HUMAN BETA-CASOMORPHIN-7'''
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===PORCINE PANCREATIC ELASTASE COMPLEXED WITH HUMAN BETA-CASOMORPHIN-7===
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==Overview==
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Mass spectrometric screening reveals that an unmodified natural heptapeptide--human beta-casomorphin-7, an internal sequence of human beta-casein that possesses opioid-like activity--reacts with porcine pancreatic elastase to form an unusually stable acyl-enzyme complex at low pH. X-ray crystallographic analysis (to 1.9 A resolution) at pH 5 shows continuous electron density linking the C-terminal isoleucine of beta-casomorphin-7 to Ser 195 through an ester bond. The structure reveals a well defined water molecule (Wat 317), equidistant between the carbon of the ester carbonyl and N epsilon 2 of His 57. Deprotonation of Wat 317 will produce a hydroxide ion positioned to attack the ester carbonyl through the favoured Burgi-Dunitz trajectory.
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(as it appears on PubMed at http://www.pubmed.gov), where 9187653 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9187653}}
==About this Structure==
==About this Structure==
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[[Category: Schofield, C J.]]
[[Category: Schofield, C J.]]
[[Category: Wilmouth, R C.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:19:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:04:42 2008''

Revision as of 21:04, 28 July 2008

Image:1qix.png

Template:STRUCTURE 1qix

PORCINE PANCREATIC ELASTASE COMPLEXED WITH HUMAN BETA-CASOMORPHIN-7

Template:ABSTRACT PUBMED 9187653

About this Structure

1QIX is a Single protein structure of sequence from Homo sapiens and Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase., Wilmouth RC, Clifton IJ, Robinson CV, Roach PL, Aplin RT, Westwood NJ, Hajdu J, Schofield CJ, Nat Struct Biol. 1997 Jun;4(6):456-62. PMID:9187653

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