1p8x

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[[Image:1p8x.gif|left|200px]]
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{{Seed}}
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[[Image:1p8x.png|left|200px]]
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{{STRUCTURE_1p8x| PDB=1p8x | SCENE= }}
{{STRUCTURE_1p8x| PDB=1p8x | SCENE= }}
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'''The Calcium-Activated C-terminal half of gelsolin'''
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===The Calcium-Activated C-terminal half of gelsolin===
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==Overview==
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Gelsolin requires activation to carry out its severing and capping activities on F-actin. Here, we present the structure of the isolated C-terminal half of gelsolin (G4-G6) at 2.0 A resolution in the presence of Ca(2+) ions. This structure completes a triptych of the states of activation of G4-G6 that illuminates its role in the function of gelsolin. Activated G4-G6 displays an open conformation, with the actin-binding site on G4 fully exposed and all three type-2 Ca(2+) sites occupied. Neither actin nor the type-l Ca(2+), which normally is sandwiched between actin and G4, is required to achieve this conformation.
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The line below this paragraph, {{ABSTRACT_PUBMED_14527664}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14527664 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14527664}}
==About this Structure==
==About this Structure==
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[[Category: Robinson, R C.]]
[[Category: Robinson, R C.]]
[[Category: Calcium-binding]]
[[Category: Calcium-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:49:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:06:08 2008''

Revision as of 21:06, 28 July 2008

Image:1p8x.png

Template:STRUCTURE 1p8x

The Calcium-Activated C-terminal half of gelsolin

Template:ABSTRACT PUBMED 14527664

About this Structure

1P8X is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Activation in isolation: exposure of the actin-binding site in the C-terminal half of gelsolin does not require actin., Narayan K, Chumnarnsilpa S, Choe H, Irobi E, Urosev D, Lindberg U, Schutt CE, Burtnick LD, Robinson RC, FEBS Lett. 2003 Sep 25;552(2-3):82-5. PMID:14527664

Page seeded by OCA on Tue Jul 29 00:06:08 2008

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