1r8n

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[[Image:1r8n.jpg|left|200px]]
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{{Seed}}
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[[Image:1r8n.png|left|200px]]
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{{STRUCTURE_1r8n| PDB=1r8n | SCENE= }}
{{STRUCTURE_1r8n| PDB=1r8n | SCENE= }}
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'''The Crystal Structure of the Kunitz (STI) Type Inhibitor from Seeds of Delonix regia'''
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===The Crystal Structure of the Kunitz (STI) Type Inhibitor from Seeds of Delonix regia===
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==Overview==
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The three-dimensional structure of a novel Kunitz (STI) family member, an inhibitor purified from Delonix regia seeds (DrTI), was solved by molecular replacement method and refined, respectively, to R(factor) and R(free) values of 21.5% and 25.3% at 1.75A resolution. The structure has a classical beta-trefoil fold, however, differently from canonical Kunitz type (STI) inhibitors, its reactive site loop has an insertion of one residue, Glu68, between the residues P1 and P2. Surprisingly, DrTI is an effective inhibitor of trypsin and human plasma kallikrein, but not of chymotrypsin and tissue kallikrein. Putative structural grounds of such specificity are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 14652016 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14652016}}
==About this Structure==
==About this Structure==
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[[Category: Kunitz-type trypsin/kallikrein inhibitor]]
[[Category: Kunitz-type trypsin/kallikrein inhibitor]]
[[Category: X-ray structure]]
[[Category: X-ray structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:13:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:10:10 2008''

Revision as of 21:10, 28 July 2008

Image:1r8n.png

Template:STRUCTURE 1r8n

The Crystal Structure of the Kunitz (STI) Type Inhibitor from Seeds of Delonix regia

Template:ABSTRACT PUBMED 14652016

About this Structure

1R8N is a Single protein structure of sequence from Delonix regia. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Kunitz (STI)-type inhibitor from Delonix regia seeds., Krauchenco S, Pando SC, Marangoni S, Polikarpov I, Biochem Biophys Res Commun. 2003 Dec 26;312(4):1303-8. PMID:14652016

Page seeded by OCA on Tue Jul 29 00:10:10 2008

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