1p7h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
 +
{{Seed}}
[[Image:1p7h.gif|left|200px]]
[[Image:1p7h.gif|left|200px]]
Line 9: Line 10:
{{STRUCTURE_1p7h| PDB=1p7h | SCENE= }}
{{STRUCTURE_1p7h| PDB=1p7h | SCENE= }}
-
'''Structure of NFAT1 bound as a dimer to the HIV-1 LTR kB element'''
+
===Structure of NFAT1 bound as a dimer to the HIV-1 LTR kB element===
-
==Overview==
+
<!--
-
DNA binding by NFAT1 as a dimer has been implicated in the activation of host and viral genes. Here we report a crystal structure of NFAT1 bound cooperatively as a dimer to the highly conserved kappa B site from the human immunodeficiency virus 1 (HIV-1) long terminal repeat (LTR). This structure reveals a new mode of dimerization and protein-DNA recognition by the Rel homology region (RHR) of NFAT1. The two NFAT1 monomers form a complete circle around the kappa B DNA through protein-protein interactions mediated by both their N- and C-terminal subdomains. The major dimer interface, formed by the C-terminal domain, is asymmetric and substantially different from the symmetric dimer interface seen in other Rel family proteins. Comparison to other NFAT structures, including NFAT5 and the NFAT1-Fos-Jun-ARRE2 complex, reveals that NFAT1 adopts different conformations and its protein surfaces mediate distinct protein-protein interactions in the context of different DNA sites.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12949493}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12949493 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12949493}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Dna binding protein]]
[[Category: Dna binding protein]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:46:49 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:18:12 2008''

Revision as of 21:18, 28 July 2008

Image:1p7h.gif

Template:STRUCTURE 1p7h

Structure of NFAT1 bound as a dimer to the HIV-1 LTR kB element

Template:ABSTRACT PUBMED 12949493

About this Structure

1P7H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element., Giffin MJ, Stroud JC, Bates DL, von Koenig KD, Hardin J, Chen L, Nat Struct Biol. 2003 Oct;10(10):800-6. Epub 2003 Aug 31. PMID:12949493

Page seeded by OCA on Tue Jul 29 00:18:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1p7h"
Personal tools