1nw3

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{{STRUCTURE_1nw3| PDB=1nw3 | SCENE= }}
{{STRUCTURE_1nw3| PDB=1nw3 | SCENE= }}
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'''Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase'''
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===Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase===
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==Overview==
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Dot1 is an evolutionarily conserved histone methyltransferase that methylates lysine-79 of histone H3 in the core domain. Unlike other histone methyltransferases, Dot1 does not contain a SET domain, and it specifically methylates nucleosomal histone H3. We have solved a 2.5 A resolution structure of the catalytic domain of human Dot1, hDOT1L, in complex with S-adenosyl-L-methionine (SAM). The structure reveals a unique organization of a mainly alpha-helical N-terminal domain and a central open alpha/beta structure, an active site consisting of a SAM binding pocket, and a potential lysine binding channel. We also show that a flexible, positively charged region at the C terminus of the catalytic domain is critical for nucleosome binding and enzymatic activity. These structural and biochemical analyses, combined with molecular modeling, provide mechanistic insights into the catalytic mechanism and nucleosomal specificity of Dot1 proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 12628190 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12628190}}
==About this Structure==
==About this Structure==
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[[Category: Hdot1]]
[[Category: Hdot1]]
[[Category: Histone lysine methyltransferase]]
[[Category: Histone lysine methyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:02:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:24:14 2008''

Revision as of 21:24, 28 July 2008

Image:1nw3.png

Template:STRUCTURE 1nw3

Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase

Template:ABSTRACT PUBMED 12628190

About this Structure

1NW3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase., Min J, Feng Q, Li Z, Zhang Y, Xu RM, Cell. 2003 Mar 7;112(5):711-23. PMID:12628190

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