1wz5

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[[Image:1wz5.gif|left|200px]]
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{{Seed}}
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[[Image:1wz5.png|left|200px]]
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{{STRUCTURE_1wz5| PDB=1wz5 | SCENE= }}
{{STRUCTURE_1wz5| PDB=1wz5 | SCENE= }}
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'''Solution structure of Pi1-3p'''
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===Solution structure of Pi1-3p===
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==Overview==
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Animal toxins are highly reticulated and structured polypeptides that adopt a limited number of folds. In scorpion species, the most represented fold is the alpha/beta scaffold in which an helical structure is connected to an antiparallel beta-sheet by two disulfide bridges. The intimate relationship existing between peptide reticulation and folding remains poorly understood. Here, we investigated the role of disulfide bridging on the 3D structure of HsTx1, a scorpion toxin potently active on Kv1.1 and Kv1.3 channels. This toxin folds along the classical alpha/beta scaffold but belongs to a unique family of short-chain, four disulfide-bridged toxins. Removal of the fourth disulfide bridge of HsTx1 does not affect its helical structure, whereas its two-stranded beta-sheet is altered from a twisted to a nontwisted configuration. This structural change in HsTx1 is accompanied by a marked decrease in Kv1.1 and Kv1.3 current blockage, and by alterations in the toxin to channel molecular contacts. In contrast, a similar removal of the fourth disulfide bridge of Pi1, another scorpion toxin from the same structural family, has no impact on its 3D structure, pharmacology, or channel interaction. These data highlight the importance of disulfide bridging in reaching the correct bioactive conformation of some toxins.
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The line below this paragraph, {{ABSTRACT_PUBMED_16247791}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16247791 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16247791}}
==About this Structure==
==About this Structure==
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1WZ5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA].
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1WZ5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pandinus_imperator Pandinus imperator]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WZ5 OCA].
==Reference==
==Reference==
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[[Category: Ionic channel inhibitor]]
[[Category: Ionic channel inhibitor]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:20:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:26:12 2008''

Revision as of 21:26, 28 July 2008

Image:1wz5.png

Template:STRUCTURE 1wz5

Solution structure of Pi1-3p

Template:ABSTRACT PUBMED 16247791

About this Structure

1WZ5 is a Single protein structure of sequence from Pandinus imperator. Full experimental information is available from OCA.

Reference

The impact of the fourth disulfide bridge in scorpion toxins of the alpha-KTx6 subfamily., Carrega L, Mosbah A, Ferrat G, Beeton C, Andreotti N, Mansuelle P, Darbon H, De Waard M, Sabatier JM, Proteins. 2005 Dec 1;61(4):1010-23. PMID:16247791

Page seeded by OCA on Tue Jul 29 00:26:12 2008

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