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2c7y

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[[Image:2c7y.gif|left|200px]]
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{{STRUCTURE_2c7y| PDB=2c7y | SCENE= }}
{{STRUCTURE_2c7y| PDB=2c7y | SCENE= }}
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'''PLANT ENZYME'''
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===PLANT ENZYME===
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==Overview==
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Crystal structures of peroxisomal Arabidopsis thaliana 3-ketoacyl-CoA thiolase (AtKAT), an enzyme of fatty acid beta-oxidation, are reported. The subunit, a typical thiolase, is a combination of two similar alpha/beta domains capped with a loop domain. The comparison of AtKAT with the Saccharomyces cerevisiae homologue (ScKAT) structure reveals a different placement of subunits within the functional dimers and that a polypeptide segment forming an extended loop around the open catalytic pocket of ScKAT converts to alpha-helix in AtKAT, and occludes the active site. A disulfide is formed between Cys192, on this helix, and Cys138, a catalytic residue. Access to Cys138 is determined by the structure of this polypeptide segment. AtKAT represents an oxidized, previously unknown inactive form, whilst ScKAT is the reduced and active enzyme. A high level of sequence conservation is observed, including Cys192, in eukaryotic peroxisomal, but not mitochondrial or prokaryotic KAT sequences, for this labile loop/helix segment. This indicates that KAT activity in peroxisomes is influenced by a disulfide/dithiol change linking fatty acid beta-oxidation with redox regulation.
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(as it appears on PubMed at http://www.pubmed.gov), where 16630629 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16630629}}
==About this Structure==
==About this Structure==
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[[Category: Oxylipin synthesis]]
[[Category: Oxylipin synthesis]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:24:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:26:18 2008''

Revision as of 21:26, 28 July 2008

Image:2c7y.png

Template:STRUCTURE 2c7y

PLANT ENZYME

Template:ABSTRACT PUBMED 16630629

About this Structure

2C7Y is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

The crystal structure of a plant 3-ketoacyl-CoA thiolase reveals the potential for redox control of peroxisomal fatty acid beta-oxidation., Sundaramoorthy R, Micossi E, Alphey MS, Germain V, Bryce JH, Smith SM, Leonard GA, Hunter WN, J Mol Biol. 2006 Jun 2;359(2):347-57. Epub 2006 Mar 29. PMID:16630629

Page seeded by OCA on Tue Jul 29 00:26:18 2008

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