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1oyi

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{{STRUCTURE_1oyi| PDB=1oyi | SCENE= }}
{{STRUCTURE_1oyi| PDB=1oyi | SCENE= }}
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'''Solution structure of the Z-DNA binding domain of the vaccinia virus gene E3L'''
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===Solution structure of the Z-DNA binding domain of the vaccinia virus gene E3L===
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==Overview==
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The N-terminal domain of the vaccinia virus protein E3L (Z alpha(E3L)) is essential for full viral pathogenicity in mice. It has sequence similarity to the high-affinity human Z-DNA-binding domains Z alpha(ADAR1) and Z alpha(DLM1). Here, we report the solution structure of Z alpha(E3L) and the chemical shift map of its interaction surface with Z-DNA. The global structure and the Z-DNA interaction surface of Z alpha(E3L) are very similar to the high-affinity Z-DNA-binding domains Z alpha(ADAR1) and Z alpha(DLM1). However, the key Z-DNA contacting residue Y48 of Z alpha(E3L) adopts a different side chain conformation in unbound Z alpha(E3L), which requires rearrangement for binding to Z-DNA. This difference suggests a molecular basis for the significantly lower in vitro affinity of Z alpha(E3L) to Z-DNA compared with its homologues.
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(as it appears on PubMed at http://www.pubmed.gov), where 14981270 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14981270}}
==About this Structure==
==About this Structure==
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1OYI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OYI OCA].
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1OYI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OYI OCA].
==Reference==
==Reference==
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[[Category: Schmieder, P.]]
[[Category: Schmieder, P.]]
[[Category: Wecking, D A.]]
[[Category: Wecking, D A.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:26:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:27:07 2008''

Revision as of 21:27, 28 July 2008

Image:1oyi.png

Template:STRUCTURE 1oyi

Solution structure of the Z-DNA binding domain of the vaccinia virus gene E3L

Template:ABSTRACT PUBMED 14981270

About this Structure

1OYI is a Single protein structure of sequence from Vaccinia virus. Full experimental information is available from OCA.

Reference

The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro., Kahmann JD, Wecking DA, Putter V, Lowenhaupt K, Kim YG, Schmieder P, Oschkinat H, Rich A, Schade M, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2712-7. Epub 2004 Feb 23. PMID:14981270

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