2hko

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{{STRUCTURE_2hko| PDB=2hko | SCENE= }}
{{STRUCTURE_2hko| PDB=2hko | SCENE= }}
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'''Crystal structure of LSD1'''
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===Crystal structure of LSD1===
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==Overview==
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Lysine-specific demethylase 1 (LSD1) was recently identified as the first histone demethylase that specifically demethylates monomethylated and dimethylated histone H3 at K4. It is a component of the CoREST and other corepressor complexes and plays an important role in silencing neuronal-specific genes in nonneuronal cells, but the molecular mechanisms of its action remain unclear. The 2.8-A-resolution crystal structure of the human LSD1 reveals that LSD1 defines a new subfamily of FAD-dependent oxidases. The active center of LSD1 is characterized by a remarkable 1,245-A3 substrate-binding cavity with a highly negative electrostatic potential. Although the protein core of LSD1 resembles other flavoenzymes, its enzymatic activity and functions require two additional structural modules: an N-terminal SWIRM domain important for protein stability and a large insertion in the catalytic domain indispensable both for the demethylase activity and the interaction with CoREST. These results provide a framework for further probing the catalytic mechanism and the functional roles of LSD1.
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(as it appears on PubMed at http://www.pubmed.gov), where 16956976 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16956976}}
==About this Structure==
==About this Structure==
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[[Category: Fad binding domain]]
[[Category: Fad binding domain]]
[[Category: Swirm domain]]
[[Category: Swirm domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:24:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:27:17 2008''

Revision as of 21:27, 28 July 2008

Image:2hko.png

Template:STRUCTURE 2hko

Crystal structure of LSD1

Template:ABSTRACT PUBMED 16956976

About this Structure

2HKO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human histone lysine-specific demethylase 1 (LSD1)., Chen Y, Yang Y, Wang F, Wan K, Yamane K, Zhang Y, Lei M, Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13956-61. Epub 2006 Sep 6. PMID:16956976

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