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2gis

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{{STRUCTURE_2gis| PDB=2gis | SCENE= }}
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'''Structure of the S-adenosylmethionine riboswitch mRNA regulatory element'''
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===Structure of the S-adenosylmethionine riboswitch mRNA regulatory element===
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==Overview==
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Riboswitches are cis-acting genetic regulatory elements found in the 5'-untranslated regions of messenger RNAs that control gene expression through their ability to bind small molecule metabolites directly. Regulation occurs through the interplay of two domains of the RNA: an aptamer domain that responds to intracellular metabolite concentrations and an expression platform that uses two mutually exclusive secondary structures to direct a decision-making process. In Gram-positive bacteria such as Bacillus species, riboswitches control the expression of more than 2% of all genes through their ability to respond to a diverse set of metabolites including amino acids, nucleobases and protein cofactors. Here we report the 2.9-angstroms resolution crystal structure of an S-adenosylmethionine (SAM)-responsive riboswitch from Thermoanaerobacter tengcongensis complexed with S-adenosylmethionine, an RNA element that controls the expression of several genes involved in sulphur and methionine metabolism. This RNA folds into a complex three-dimensional architecture that recognizes almost every functional group of the ligand through a combination of direct and indirect readout mechanisms. Ligand binding induces the formation of a series of tertiary interactions with one of the helices, serving as a communication link between the aptamer and expression platform domains.
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(as it appears on PubMed at http://www.pubmed.gov), where 16810258 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16810258}}
==About this Structure==
==About this Structure==
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[[Category: S-adenosylmethionine]]
[[Category: S-adenosylmethionine]]
[[Category: Sam]]
[[Category: Sam]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:09:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:28:02 2008''

Revision as of 21:28, 28 July 2008

Image:2gis.png

Template:STRUCTURE 2gis

Structure of the S-adenosylmethionine riboswitch mRNA regulatory element

Template:ABSTRACT PUBMED 16810258

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of the S-adenosylmethionine riboswitch regulatory mRNA element., Montange RK, Batey RT, Nature. 2006 Jun 29;441(7097):1172-5. PMID:16810258

Page seeded by OCA on Tue Jul 29 00:28:02 2008

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