1yk7

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[[Image:1yk7.gif|left|200px]]
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{{STRUCTURE_1yk7| PDB=1yk7 | SCENE= }}
{{STRUCTURE_1yk7| PDB=1yk7 | SCENE= }}
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'''Cathepsin K complexed with a cyanopyrrolidine inhibitor'''
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===Cathepsin K complexed with a cyanopyrrolidine inhibitor===
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==Overview==
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Starting from a PDE IV inhibitor hit derived from high throughput screening of the compound collection, a key pyrrolidine cyanamide pharmacophore was identified. Modifications of the pyrrolidine ring produced enhancements in cathepsin K inhibition. An X-ray co-crystal structure of a cyanamide with cathepsin K confirmed the mode of inhibition.
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(as it appears on PubMed at http://www.pubmed.gov), where 15780613 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15780613}}
==About this Structure==
==About this Structure==
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[[Category: Cysteine]]
[[Category: Cysteine]]
[[Category: Protease]]
[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:25:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:29:54 2008''

Revision as of 21:30, 28 July 2008

Image:1yk7.png

Template:STRUCTURE 1yk7

Cathepsin K complexed with a cyanopyrrolidine inhibitor

Template:ABSTRACT PUBMED 15780613

About this Structure

1YK7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel and potent cyclic cyanamide-based cathepsin K inhibitors., Deaton DN, Hassell AM, McFadyen RB, Miller AB, Miller LR, Shewchuk LM, Tavares FX, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2005 Apr 1;15(7):1815-9. PMID:15780613

Page seeded by OCA on Tue Jul 29 00:29:54 2008

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