1q1m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1q1m.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1q1m.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1q1m| PDB=1q1m | SCENE= }}
{{STRUCTURE_1q1m| PDB=1q1m | SCENE= }}
-
'''A Highly Efficient Approach to a Selective and Cell Active PTP1B inhibitors'''
+
===A Highly Efficient Approach to a Selective and Cell Active PTP1B inhibitors===
-
==Overview==
+
<!--
-
Using an NMR-based fragment screening and X-ray crystal structure-based assembly, starting with millimolar ligands for both the catalytic site and the second phosphotyrosine binding site, we have identified a small-molecule inhibitor of protein tyrosine phosphatase 1B with low micromolar inhibition constant, high selectivity (30-fold) over the highly homologous T-cell protein tyrosine phosphatase, and good cellular activity in COS-7 cells.
+
The line below this paragraph, {{ABSTRACT_PUBMED_13678400}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 13678400 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_13678400}}
==About this Structure==
==About this Structure==
Line 40: Line 44:
[[Category: Protein tyrosine phosphatase 1b]]
[[Category: Protein tyrosine phosphatase 1b]]
[[Category: Ptp1b]]
[[Category: Ptp1b]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:45:19 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:30:14 2008''

Revision as of 21:30, 28 July 2008

Image:1q1m.png

Template:STRUCTURE 1q1m

A Highly Efficient Approach to a Selective and Cell Active PTP1B inhibitors

Template:ABSTRACT PUBMED 13678400

About this Structure

1Q1M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor., Liu G, Xin Z, Pei Z, Hajduk PJ, Abad-Zapatero C, Hutchins CW, Zhao H, Lubben TH, Ballaron SJ, Haasch DL, Kaszubska W, Rondinone CM, Trevillyan JM, Jirousek MR, J Med Chem. 2003 Sep 25;46(20):4232-5. PMID:13678400

Page seeded by OCA on Tue Jul 29 00:30:14 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1q1m"
Personal tools