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1y14

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{{STRUCTURE_1y14| PDB=1y14 | SCENE= }}
{{STRUCTURE_1y14| PDB=1y14 | SCENE= }}
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'''Crystal structure of yeast subcomplex of Rpb4 and Rpb7'''
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===Crystal structure of yeast subcomplex of Rpb4 and Rpb7===
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==Overview==
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We determined the x-ray structure of the RNA polymerase (Pol) II subcomplex Rpb4/7 at 2.3 A resolution, combined it with a previous structure of the 10-subunit polymerase core, and refined an atomic model of the complete 12-subunit Pol II at 3.8-A resolution. Comparison of the complete Pol II structure with structures of the Pol II core and free Rpb4/7 shows that the core-Rpb4/7 interaction goes along with formation of an alpha-helix in the linker region of the largest Pol II subunit and with folding of the conserved Rpb7 tip loop. Details of the core-Rpb4/7 interface explain facilitated Rpb4/7 dissociation in a temperature-sensitive Pol II mutant and specific assembly of Pol I with its Rpb4/7 counterpart, A43/14. The refined atomic model of Pol II serves as the new reference structure for analysis of the transcription mechanism and enables structure solution of complexes of the complete enzyme with additional factors and nucleic acids by molecular replacement.
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{{ABSTRACT_PUBMED_15591044}}
==About this Structure==
==About this Structure==
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[[Category: Mitterweger, S.]]
[[Category: Mitterweger, S.]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:45:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:32:00 2008''

Revision as of 21:32, 28 July 2008

Image:1y14.png

Template:STRUCTURE 1y14

Crystal structure of yeast subcomplex of Rpb4 and Rpb7

Template:ABSTRACT PUBMED 15591044

About this Structure

1Y14 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structures of complete RNA polymerase II and its subcomplex, Rpb4/7., Armache KJ, Mitterweger S, Meinhart A, Cramer P, J Biol Chem. 2005 Feb 25;280(8):7131-4. Epub 2004 Dec 9. PMID:15591044

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