2i0j

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[[Image:2i0j.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2i0j| PDB=2i0j | SCENE= }}
{{STRUCTURE_2i0j| PDB=2i0j | SCENE= }}
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'''Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia'''
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===Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia===
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==Overview==
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Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows potent, selective binding and agonist function in estrogen receptor beta (ERbeta) in vitro assays. X-ray crystal structures of SERBA-1 in ERalpha and beta help explain observed beta-selectivity of this ligand. SERBA-1 in vivo demonstrates involution of the ventral prostate in CD-1 mice (ERbeta effect), while having no effect on gonadal hormone levels (ERalpha effect) at 10x the efficacious dose, consistent with in vitro properties of this molecule.
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(as it appears on PubMed at http://www.pubmed.gov), where 17034120 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17034120}}
==About this Structure==
==About this Structure==
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[[Category: Wang, Y.]]
[[Category: Wang, Y.]]
[[Category: Nuclear receptor ligand binding domain]]
[[Category: Nuclear receptor ligand binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:33:05 2008''

Revision as of 21:33, 28 July 2008

Template:STRUCTURE 2i0j

Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia

Template:ABSTRACT PUBMED 17034120

About this Structure

2I0J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Benzopyrans are selective estrogen receptor beta agonists with novel activity in models of benign prostatic hyperplasia., Norman BH, Dodge JA, Richardson TI, Borromeo PS, Lugar CW, Jones SA, Chen K, Wang Y, Durst GL, Barr RJ, Montrose-Rafizadeh C, Osborne HE, Amos RM, Guo S, Boodhoo A, Krishnan V, J Med Chem. 2006 Oct 19;49(21):6155-7. PMID:17034120

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