2of6

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[[Image:2of6.gif|left|200px]]
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{{STRUCTURE_2of6| PDB=2of6 | SCENE= }}
{{STRUCTURE_2of6| PDB=2of6 | SCENE= }}
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'''Structure of immature West Nile virus'''
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===Structure of immature West Nile virus===
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==Overview==
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The structure of immature West Nile virus particles, propagated in the presence of ammonium chloride to block virus maturation in the low-pH environment of the trans-Golgi network, was determined by cryo-electron microscopy (cryo-EM). The structure of these particles was similar to that of immature West Nile virus particles found as a minor component of mature virus samples (naturally occurring immature particles [NOIPs]). The structures of mature infectious flaviviruses are radically different from those of the immature particles. The similarity of the ammonium chloride-treated particles and NOIPs suggests either that the NOIPs have not undergone any conformational change during maturation or that the conformational change is reversible. Comparison with the cryo-EM reconstruction of immature dengue virus established the locations of the N-linked glycosylation sites of these viruses, verifying the interpretation of the reconstructions of the immature flaviviruses.
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The line below this paragraph, {{ABSTRACT_PUBMED_17376919}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17376919 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17376919}}
==About this Structure==
==About this Structure==
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[[Category: Em immature flavivirus west nile]]
[[Category: Em immature flavivirus west nile]]
[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:46:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:38:19 2008''

Revision as of 21:38, 28 July 2008

Image:2of6.png

Template:STRUCTURE 2of6

Structure of immature West Nile virus

Template:ABSTRACT PUBMED 17376919

About this Structure

2OF6 is a Single protein structure of sequence from West nile virus. Full crystallographic information is available from OCA.

Reference

Structure of immature West Nile virus., Zhang Y, Kaufmann B, Chipman PR, Kuhn RJ, Rossmann MG, J Virol. 2007 Jun;81(11):6141-5. Epub 2007 Mar 21. PMID:17376919

Page seeded by OCA on Tue Jul 29 00:38:19 2008

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