2iws

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{{STRUCTURE_2iws| PDB=2iws | SCENE= }}
{{STRUCTURE_2iws| PDB=2iws | SCENE= }}
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'''RADICICOL ANALOGUES BOUND TO THE ATP SITE OF HSP90'''
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===RADICICOL ANALOGUES BOUND TO THE ATP SITE OF HSP90===
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==Overview==
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A series of benzo-macrolactones of varying ring size and conformation has been prepared by chemical synthesis and evaluated by structural and biological techniques. Thus, 12- to 16-membered lactones were obtained by concise routes, involving ring-closing metathesis as a key step. In enzyme assays, the 13-, 15-, and 16-membered analogs are good inhibitors, suggesting that they can adopt the required conformation to fit in the ATP-binding site. This was confirmed by cocrystallization of 13-, 14-, and 15-membered lactones with the N-terminal domain of yeast Hsp90, showing that they bind similarly to the "natural" 14-membered radicicol. The most active compounds in the ATPase assays also showed the greatest growth-inhibitory potency in HCT116 human colon cancer cells and the established molecular signature of Hsp90 inhibition, i.e., depletion of client proteins with upregulation of Hsp70.
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{{ABSTRACT_PUBMED_17114002}}
==About this Structure==
==About this Structure==
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[[Category: Multigene family]]
[[Category: Multigene family]]
[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:00:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:41:25 2008''

Revision as of 21:41, 28 July 2008

Image:2iws.png

Template:STRUCTURE 2iws

RADICICOL ANALOGUES BOUND TO THE ATP SITE OF HSP90

Template:ABSTRACT PUBMED 17114002

About this Structure

2IWS is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol., Proisy N, Sharp SY, Boxall K, Connelly S, Roe SM, Prodromou C, Slawin AM, Pearl LH, Workman P, Moody CJ, Chem Biol. 2006 Nov;13(11):1203-15. PMID:17114002

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