2het

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[[Image:2het.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2het| PDB=2het | SCENE= }}
{{STRUCTURE_2het| PDB=2het | SCENE= }}
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'''Non-myristoylated bovine recoverin (truncated at C-terminus) with calcium bound to EF-hand 3'''
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===Non-myristoylated bovine recoverin (truncated at C-terminus) with calcium bound to EF-hand 3===
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==Overview==
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Recoverin is a Ca(2+)-regulated signal transduction modulator expressed in the vertebrate retina that has been implicated in visual adaptation. An intriguing feature of recoverin is a cluster of charged residues at its C terminus, the functional significance of which is largely unclear. To elucidate the impact of this segment on recoverin structure and function, we have investigated a mutant lacking the C-terminal 12 amino acids. Whereas in myristoylated recoverin the truncation causes an overall decrease in Ca(2+) sensitivity, results for the non-myristoylated mutant indicate that the truncation primarily affects the high affinity EF-hand 3. The three-dimensional structure of the mutant has been determined by x-ray crystallography. In addition to significant changes in average coordinates compared with wild-type recoverin, the structure provides strong indication of increased conformational flexibility, particularly in the C-terminal domain. Based on these observations, we propose a novel role of the C-terminal segment of recoverin as an internal modulator of Ca(2+) sensitivity.
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The line below this paragraph, {{ABSTRACT_PUBMED_17015448}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17015448 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17015448}}
==About this Structure==
==About this Structure==
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[[Category: Helix-loop-helix]]
[[Category: Helix-loop-helix]]
[[Category: Recoverin]]
[[Category: Recoverin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:12:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:41:51 2008''

Revision as of 21:41, 28 July 2008

Image:2het.png

Template:STRUCTURE 2het

Non-myristoylated bovine recoverin (truncated at C-terminus) with calcium bound to EF-hand 3

Template:ABSTRACT PUBMED 17015448

About this Structure

2HET is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Tuning of a neuronal calcium sensor., Weiergraber OH, Senin II, Zernii EY, Churumova VA, Kovaleva NA, Nazipova AA, Permyakov SE, Permyakov EA, Philippov PP, Granzin J, Koch KW, J Biol Chem. 2006 Dec 8;281(49):37594-602. Epub 2006 Oct 2. PMID:17015448

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