1jax

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{{STRUCTURE_1jax| PDB=1jax | SCENE= }}
{{STRUCTURE_1jax| PDB=1jax | SCENE= }}
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'''Structure of Coenzyme F420H2:NADP+ Oxidoreductase (FNO)'''
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===Structure of Coenzyme F420H2:NADP+ Oxidoreductase (FNO)===
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==Overview==
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Cofactor F420 is a 5'-deazaflavin derivative first discovered in methanogenic archaea but later found also to be present in some bacteria. As a coenzyme, it is involved in hydride transfer reactions and as a prosthetic group in the DNA photolyase reaction. We report here for the first time on the crystal structure of an F420-dependent oxidoreductase bound with F420. The structure of F420H2:NADP+ oxidoreductase resolved to 1.65 A contains two domains: an N-terminal domain characteristic of a dinucleotide-binding Rossmann fold and a smaller C-terminal domain. The nicotinamide and the deazaflavin part of the two coenzymes are bound in the cleft between the domains such that the Si-faces of both face each other at a distance of 3.1 A, which is optimal for hydride transfer. Comparison of the structures bound with and without substrates reveals that of the two substrates NADP has to bind first, the binding being associated with an induced fit.
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The line below this paragraph, {{ABSTRACT_PUBMED_11726492}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11726492 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11726492}}
==About this Structure==
==About this Structure==
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[[Category: Warkentin, E.]]
[[Category: Warkentin, E.]]
[[Category: Rossman fold]]
[[Category: Rossman fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:59:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:42:19 2008''

Revision as of 21:42, 28 July 2008

Image:1jax.png

Template:STRUCTURE 1jax

Structure of Coenzyme F420H2:NADP+ Oxidoreductase (FNO)

Template:ABSTRACT PUBMED 11726492

About this Structure

1JAX is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

Structures of F420H2:NADP+ oxidoreductase with and without its substrates bound., Warkentin E, Mamat B, Sordel-Klippert M, Wicke M, Thauer RK, Iwata M, Iwata S, Ermler U, Shima S, EMBO J. 2001 Dec 3;20(23):6561-9. PMID:11726492

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