2fug

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{{STRUCTURE_2fug| PDB=2fug | SCENE= }}
{{STRUCTURE_2fug| PDB=2fug | SCENE= }}
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'''Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus'''
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===Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus===
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==Overview==
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Respiratory complex I plays a central role in cellular energy production in bacteria and mitochondria. Its dysfunction is implicated in many human neurodegenerative diseases, as well as in aging. The crystal structure of the hydrophilic domain (peripheral arm) of complex I from Thermus thermophilus has been solved at 3.3 angstrom resolution. This subcomplex consists of eight subunits and contains all the redox centers of the enzyme, including nine iron-sulfur clusters. The primary electron acceptor, flavin-mononucleotide, is within electron transfer distance of cluster N3, leading to the main redox pathway, and of the distal cluster N1a, a possible antioxidant. The structure reveals new aspects of the mechanism and evolution of the enzyme. The terminal cluster N2 is coordinated, uniquely, by two consecutive cysteines. The novel subunit Nqo15 has a similar fold to the mitochondrial iron chaperone frataxin, and it may be involved in iron-sulfur cluster regeneration in the complex.
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The line below this paragraph, {{ABSTRACT_PUBMED_16469879}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16469879 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16469879}}
==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Respiratory chain]]
[[Category: Respiratory chain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:19:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:44:46 2008''

Revision as of 21:44, 28 July 2008

Image:2fug.png

Template:STRUCTURE 2fug

Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

Template:ABSTRACT PUBMED 16469879

About this Structure

2FUG is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus., Sazanov LA, Hinchliffe P, Science. 2006 Mar 10;311(5766):1430-6. Epub 2006 Feb 9. PMID:16469879

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