2o0o

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[[Image:2o0o.gif|left|200px]]
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{{STRUCTURE_2o0o| PDB=2o0o | SCENE= }}
{{STRUCTURE_2o0o| PDB=2o0o | SCENE= }}
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'''Crystal structure of TL1A'''
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===Crystal structure of TL1A===
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==Overview==
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The TNF family has been one of the most intensively studied protein families in the past two decades and it has rapidly expanded through the era of genomics and bioinformatics. However, the structural basis of the functional and interactional similarities and differences of this family is poorly understood. TL1A is a recently identified TNF family member that has received increasing attention. Here, the crystal structure of human TL1A is reported. TL1A forms a homotrimer with each monomer assuming a jellyroll beta-sandwich fold. The CD loop in TL1A is the longest among the TNF ligand members with known structure and the AA' loop in TL1A is the second longest after that in TRAIL, where part of it is disordered. Both these loops are known to participate in receptor binding in TNFbeta/LTalpha. The AA' loop may be very different in other TL1A variants if the overall fold is to be preserved.
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(as it appears on PubMed at http://www.pubmed.gov), where 17935696 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17935696}}
==About this Structure==
==About this Structure==
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[[Category: Metal binding]]
[[Category: Metal binding]]
[[Category: Vegi]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:09:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:44:55 2008''

Revision as of 21:45, 28 July 2008

Image:2o0o.png

Template:STRUCTURE 2o0o

Crystal structure of TL1A

Template:ABSTRACT PUBMED 17935696

About this Structure

2O0O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of TNF ligand family member TL1A at 2.1A., Jin T, Guo F, Kim S, Howard A, Zhang YZ, Biochem Biophys Res Commun. 2007 Dec 7;364(1):1-6. Epub 2007 Oct 1. PMID:17935696

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