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1yx4

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[[Image:1yx4.gif|left|200px]]
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{{STRUCTURE_1yx4| PDB=1yx4 | SCENE= }}
{{STRUCTURE_1yx4| PDB=1yx4 | SCENE= }}
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'''Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition'''
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===Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition===
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==Overview==
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Ubiquitin is a key regulatory molecule in diverse cellular events. How cells determine the outcome of ubiquitylation remains unclear; however, a likely determinant is the specificity of ubiquitin receptor proteins for polyubiquitin chains of certain length and linkage. Proteasome subunit S5a contains two ubiquitin-interacting motifs (UIMs) through which it recruits ubiquitylated substrates to the proteasome for their degradation. Here, we report the structure of S5a (196-306) alone and complexed with two monoubiquitin molecules. This construct contains the two UIMs of S5a and we reveal their different ubiquitin-binding mechanisms and provide a rationale for their unique specificities for different ubiquitin-like domains. Furthermore, we provide direct evidence that S5a (196-306) binds either K63-linked or K48-linked polyubiquitin, and in both cases prefers longer chains. On the basis of these results we present a model for how S5a and other ubiquitin-binding proteins recognize polyubiquitin.
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The line below this paragraph, {{ABSTRACT_PUBMED_15826667}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15826667 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15826667}}
==About this Structure==
==About this Structure==
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1YX4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YX4 OCA].
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1YX4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YX4 OCA].
==Reference==
==Reference==
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[[Category: S5a]]
[[Category: S5a]]
[[Category: Uim]]
[[Category: Uim]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:54:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:47:19 2008''

Revision as of 21:47, 28 July 2008

Image:1yx4.png

Template:STRUCTURE 1yx4

Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition

Template:ABSTRACT PUBMED 15826667

About this Structure

1YX4 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition., Wang Q, Young P, Walters KJ, J Mol Biol. 2005 May 6;348(3):727-39. PMID:15826667

Page seeded by OCA on Tue Jul 29 00:47:19 2008

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