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2foj

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[[Image:2foj.gif|left|200px]]
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{{STRUCTURE_2foj| PDB=2foj | SCENE= }}
{{STRUCTURE_2foj| PDB=2foj | SCENE= }}
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'''The Crystal Strucure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 364-367'''
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===The Crystal Strucure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 364-367===
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==Overview==
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The ubiquitin-specific protease, USP7, has key roles in the p53 pathway whereby it stabilizes both p53 and MDM2. We show that the N-terminal domain of USP7 binds two closely spaced 4-residue sites in both p53 and MDM2, falling between p53 residues 359-367 and MDM2 residues 147-159. Cocrystal structures with USP7 were determined for both p53 peptides and for one MDM2 peptide. These peptides bind the same surface of USP7 as Epstein-Barr nuclear antigen-1, explaining the competitive nature of the interactions. The structures and mutagenesis data indicate a preference for a P/AXXS motif in peptides that bind USP7. Contacts made by serine are identical and crucial for all peptides, and Trp165 in the peptide-binding pocket of USP7 is also crucial. These results help to elucidate the mechanism of substrate recognition by USP7 and the regulation of the p53 pathway.
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(as it appears on PubMed at http://www.pubmed.gov), where 16474402 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16474402}}
==About this Structure==
==About this Structure==
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[[Category: Wu, T.]]
[[Category: Wu, T.]]
[[Category: Math domain]]
[[Category: Math domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:08:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:47:25 2008''

Revision as of 21:47, 28 July 2008

Image:2foj.png

Template:STRUCTURE 2foj

The Crystal Strucure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 364-367

Template:ABSTRACT PUBMED 16474402

About this Structure

2FOJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular recognition of p53 and MDM2 by USP7/HAUSP., Sheng Y, Saridakis V, Sarkari F, Duan S, Wu T, Arrowsmith CH, Frappier L, Nat Struct Mol Biol. 2006 Mar;13(3):285-91. Epub 2006 Feb 12. PMID:16474402

Page seeded by OCA on Tue Jul 29 00:47:25 2008

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