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1tex

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{{STRUCTURE_1tex| PDB=1tex | SCENE= }}
{{STRUCTURE_1tex| PDB=1tex | SCENE= }}
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'''Mycobacterium smegmatis Stf0 Sulfotransferase with Trehalose'''
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===Mycobacterium smegmatis Stf0 Sulfotransferase with Trehalose===
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==Overview==
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Sulfolipid-1 (SL-1) is an abundant sulfated glycolipid and potential virulence factor found in Mycobacterium tuberculosis. SL-1 consists of a trehalose-2-sulfate (T2S) disaccharide elaborated with four lipids. We identified and characterized a conserved mycobacterial sulfotransferase, Stf0, which generates the T2S moiety of SL-1. Biochemical studies demonstrated that the enzyme requires unmodified trehalose as substrate and is sensitive to small structural perturbations of the disaccharide. Disruption of stf0 in Mycobacterium smegmatis and M. tuberculosis resulted in the loss of T2S and SL-1 formation, respectively. The structure of Stf0 at a resolution of 2.6 A reveals the molecular basis of trehalose recognition and a unique dimer configuration that encloses the substrate into a bipartite active site. These data provide strong evidence that Stf0 carries out the first committed step in the biosynthesis of SL-1 and establish a system for probing the role of SL-1 in M. tuberculosis infection.
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(as it appears on PubMed at http://www.pubmed.gov), where 15258569 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15258569}}
==About this Structure==
==About this Structure==
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[[Category: Trehalose]]
[[Category: Trehalose]]
[[Category: Trehalose-2-sulfate]]
[[Category: Trehalose-2-sulfate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:52:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:53:22 2008''

Revision as of 21:53, 28 July 2008

Image:1tex.png

Template:STRUCTURE 1tex

Mycobacterium smegmatis Stf0 Sulfotransferase with Trehalose

Template:ABSTRACT PUBMED 15258569

About this Structure

1TEX is a Single protein structure of sequence from Mycobacterium smegmatis. Full crystallographic information is available from OCA.

Reference

Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis., Mougous JD, Petzold CJ, Senaratne RH, Lee DH, Akey DL, Lin FL, Munchel SE, Pratt MR, Riley LW, Leary JA, Berger JM, Bertozzi CR, Nat Struct Mol Biol. 2004 Aug;11(8):721-9. Epub 2004 Jul 18. PMID:15258569

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