1ogm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ogm.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ogm.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ogm| PDB=1ogm | SCENE= }}
{{STRUCTURE_1ogm| PDB=1ogm | SCENE= }}
-
'''DEX49A FROM PENICILLIUM MINIOLUTEUM'''
+
===DEX49A FROM PENICILLIUM MINIOLUTEUM===
-
==Overview==
+
<!--
-
Dextranase catalyzes the hydrolysis of the alpha-1,6-glycosidic linkage in dextran polymers. The structure of dextranase, Dex49A, from Penicillium minioluteum was solved in the apo-enzyme and product-bound forms. The main domain of the enzyme is a right-handed parallel beta helix, which is connected to a beta sandwich domain at the N terminus. In the structure of the product complex, isomaltose was found to bind in a crevice on the surface of the enzyme. The glycosidic oxygen of the glucose unit in subsite +1 forms a hydrogen bond to the suggested catalytic acid, Asp395. By NMR spectroscopy the reaction course was shown to occur with net inversion at the anomeric carbon, implying a single displacement mechanism. Both Asp376 and Asp396 are suitably positioned to activate the water molecule that performs the nucleophilic attack. A new clan that links glycoside hydrolase families 28 and 49 is suggested.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12962629}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12962629 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12962629}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Glycosidase]]
[[Category: Glycosidase]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:49:14 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:53:37 2008''

Revision as of 21:53, 28 July 2008

Image:1ogm.png

Template:STRUCTURE 1ogm

DEX49A FROM PENICILLIUM MINIOLUTEUM

Template:ABSTRACT PUBMED 12962629

About this Structure

1OGM is a Single protein structure of sequence from Penicillium minioluteum. Full crystallographic information is available from OCA.

Reference

Dextranase from Penicillium minioluteum: reaction course, crystal structure, and product complex., Larsson AM, Andersson R, Stahlberg J, Kenne L, Jones TA, Structure. 2003 Sep;11(9):1111-21. PMID:12962629

Page seeded by OCA on Tue Jul 29 00:53:37 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ogm"
Personal tools