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1ufi

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{{STRUCTURE_1ufi| PDB=1ufi | SCENE= }}
{{STRUCTURE_1ufi| PDB=1ufi | SCENE= }}
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'''Crystal structure of the dimerization domain of human CENP-B'''
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===Crystal structure of the dimerization domain of human CENP-B===
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==Overview==
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The human centromere protein B (CENP-B), a centromeric heterochromatin component, forms a homodimer that specifically binds to a distinct DNA sequence (the CENP-B box), which appears within every other alpha-satellite repeat. Previously, we determined the structure of the human CENP-B DNA-binding domain, CENP-B-(1-129), complexed with the CENP-B box DNA. In the present study, we determined the crystal structure of its dimerization domain (CENP-B-(540-599)), another functional domain of CENP-B, at 1.65-A resolution. CENP-B-(540-599) contains two alpha-helices, which are folded into an antiparallel configuration. The CENP-B-(540-599) dimer formed a symmetrical, antiparallel, four-helix bundle structure with a large hydrophobic patch in which 23 residues of one monomer form van der Waals contacts with the other monomer. In the CENP-B-(540-599) dimer, the N-terminal ends of CENP-B-(540-599) are oriented on opposite sides of the dimer. This CENP-B dimer configuration may be suitable for capturing two distant CENP-B boxes during centromeric heterochromatin formation.
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(as it appears on PubMed at http://www.pubmed.gov), where 14522975 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14522975}}
==About this Structure==
==About this Structure==
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[[Category: Salt bridge]]
[[Category: Salt bridge]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:08:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:02:49 2008''

Revision as of 22:03, 28 July 2008

Image:1ufi.png

Template:STRUCTURE 1ufi

Crystal structure of the dimerization domain of human CENP-B

Template:ABSTRACT PUBMED 14522975

About this Structure

1UFI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human centromere protein B (CENP-B) dimerization domain at 1.65-A resolution., Tawaramoto MS, Park SY, Tanaka Y, Nureki O, Kurumizaka H, Yokoyama S, J Biol Chem. 2003 Dec 19;278(51):51454-61. Epub 2003 Sep 30. PMID:14522975

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