1yks

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{{STRUCTURE_1yks| PDB=1yks | SCENE= }}
{{STRUCTURE_1yks| PDB=1yks | SCENE= }}
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'''Crystal structure of yellow fever virus NS3 helicase'''
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===Crystal structure of yellow fever virus NS3 helicase===
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==Overview==
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Yellow fever virus (YFV), a member of the Flavivirus genus, has a plus-sense RNA genome encoding a single polyprotein. Viral protein NS3 includes a protease and a helicase that are essential to virus replication and to RNA capping. The 1.8-A crystal structure of the helicase region of the YFV NS3 protein includes residues 187 to 623. Two familiar helicase domains bind nucleotide in a triphosphate pocket without base recognition, providing a site for nonspecific hydrolysis of nucleoside triphosphates and RNA triphosphate. The third, C-terminal domain has a unique structure and is proposed to function in RNA and protein recognition. The organization of the three domains indicates that cleavage of the viral polyprotein NS3-NS4A junction occurs in trans.
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(as it appears on PubMed at http://www.pubmed.gov), where 16051820 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16051820}}
==About this Structure==
==About this Structure==
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[[Category: Rtpase]]
[[Category: Rtpase]]
[[Category: Yellow fever virus]]
[[Category: Yellow fever virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:26:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:07:34 2008''

Revision as of 22:07, 28 July 2008

Image:1yks.png

Template:STRUCTURE 1yks

Crystal structure of yellow fever virus NS3 helicase

Template:ABSTRACT PUBMED 16051820

About this Structure

1YKS is a Single protein structure of sequence from Yellow fever virus. Full crystallographic information is available from OCA.

Reference

Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing., Wu J, Bera AK, Kuhn RJ, Smith JL, J Virol. 2005 Aug;79(16):10268-77. PMID:16051820

Page seeded by OCA on Tue Jul 29 01:07:34 2008

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