2c38

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2c38.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2c38.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2c38| PDB=2c38 | SCENE= }}
{{STRUCTURE_2c38| PDB=2c38 | SCENE= }}
-
'''RNASE PH CORE OF THE ARCHAEAL EXOSOME IN COMPLEX WITH A5 RNA'''
+
===RNASE PH CORE OF THE ARCHAEAL EXOSOME IN COMPLEX WITH A5 RNA===
-
==Overview==
+
<!--
-
The exosome is a macromolecular complex that plays fundamental roles in the biogenesis and turnover of a large number of RNA species. Here we report the crystal structures of the Rrp41-Rrp42 core complex of the S. solfataricus exosome bound to short single-stranded RNAs and to ADP. The RNA binding cleft recognizes four nucleotides in a sequence-unspecific manner, mainly by electrostatic interactions with the phosphate groups. Interactions at the 2' hydroxyls of the sugars provide specificity for RNA over DNA. The structures show both the bound substrate and the cleaved product of the reaction, suggesting a catalytic mechanism for the 3'-5' phosphorolytic activity of the exosome.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16285928}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16285928 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16285928}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Rrp41]]
[[Category: Rrp41]]
[[Category: Rrp42]]
[[Category: Rrp42]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:10:50 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:13:58 2008''

Revision as of 22:13, 28 July 2008

Image:2c38.png

Template:STRUCTURE 2c38

RNASE PH CORE OF THE ARCHAEAL EXOSOME IN COMPLEX WITH A5 RNA

Template:ABSTRACT PUBMED 16285928

About this Structure

2C38 is a Protein complex structure of sequences from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

Structural basis of 3' end RNA recognition and exoribonucleolytic cleavage by an exosome RNase PH core., Lorentzen E, Conti E, Mol Cell. 2005 Nov 11;20(3):473-81. PMID:16285928

Page seeded by OCA on Tue Jul 29 01:13:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2c38"
Personal tools