2j37

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[[Image:2j37.gif|left|200px]]
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{{Seed}}
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[[Image:2j37.png|left|200px]]
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{{STRUCTURE_2j37| PDB=2j37 | SCENE= }}
{{STRUCTURE_2j37| PDB=2j37 | SCENE= }}
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'''MODEL OF MAMMALIAN SRP BOUND TO 80S RNCS'''
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===MODEL OF MAMMALIAN SRP BOUND TO 80S RNCS===
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==Overview==
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Membrane and secretory proteins can be co-translationally inserted into or translocated across the membrane. This process is dependent on signal sequence recognition on the ribosome by the signal recognition particle (SRP), which results in targeting of the ribosome-nascent-chain complex to the protein-conducting channel at the membrane. Here we present an ensemble of structures at subnanometre resolution, revealing the signal sequence both at the ribosomal tunnel exit and in the bacterial and eukaryotic ribosome-SRP complexes. Molecular details of signal sequence interaction in both prokaryotic and eukaryotic complexes were obtained by fitting high-resolution molecular models. The signal sequence is presented at the ribosomal tunnel exit in an exposed position ready for accommodation in the hydrophobic groove of the rearranged SRP54 M domain. Upon ribosome binding, the SRP54 NG domain also undergoes a conformational rearrangement, priming it for the subsequent docking reaction with the NG domain of the SRP receptor. These findings provide the structural basis for improving our understanding of the early steps of co-translational protein sorting.
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The line below this paragraph, {{ABSTRACT_PUBMED_17086193}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17086193 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17086193}}
==About this Structure==
==About this Structure==
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[[Category: Srp]]
[[Category: Srp]]
[[Category: Translation/rna]]
[[Category: Translation/rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:16:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:25:03 2008''

Revision as of 22:25, 28 July 2008

Image:2j37.png

Template:STRUCTURE 2j37

MODEL OF MAMMALIAN SRP BOUND TO 80S RNCS

Template:ABSTRACT PUBMED 17086193

About this Structure

2J37 is a Protein complex structure of sequences from Canis lupus familiaris, Canis sp., Haloarcula marismortui, Homo sapiens and Triticum aestivum. Full crystallographic information is available from OCA.

Reference

Following the signal sequence from ribosomal tunnel exit to signal recognition particle., Halic M, Blau M, Becker T, Mielke T, Pool MR, Wild K, Sinning I, Beckmann R, Nature. 2006 Nov 23;444(7118):507-11. Epub 2006 Oct 29. PMID:17086193

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